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Copyright 2013, Wilke Resources Inc.
14321 W. 96th Terrace, Lenexa, KS 66215
Toll Free Phone:  (800) 779-5545


GlucodOX™ - Natural metabolic support*
(GU-MCT810 Commiphora mukul)

GlucodOX™ is a proprietary nutraceutical ingredient complex that includes a Commiphora mukul (guggul) extract and a medium-chain triglyceride (MCT) oil composed of C8 and C10 fatty acids. In order to optimize the guggul extract, we utilize a supercritical CO2-co-solvent extraction with ethanol. The result is a concentrated extract containing active guggulsterones, which are standardized to 2.0% by HPLC analysis. The guggulsterones in GlucodOX™ are reportedly linked to several mechanisms that support healthy lipid metabolism, glucose metabolism, and cellular energy.* 

This metabolic and energy support is further enhanced by blending the extract with natural-origin MCT oil. MCTs also promote healthy energy production by gaining rapid access to the mitochondria (the energy producing organelle in cells). Given the high energy density, the rapid rate of absorption, and the quick metabolic conversion into cellular energy, MCTs naturally complement the guggulsterone’s activity and give GlucodOX™ its unique performance characteristics.

Research shows the beneficial mechanisms of GlucodOX™ can help:

  1. Promote cellular glucose uptake by significantly promoting insulin sensitivity* [2-7, 19]
  1. Support cholesterol levels already within the normal range by inhibiting its natural production (Regulate HMG-CoA reductase).* [17, 20]
  1. Regulate balanced transformation of pre-adipocytes to adipocytes (i.e. fat cells) and regulate triglyceride storage.* [11, 12, 18, 20, 21]
  1. Stimulate AMPK activity—the nutrient/energy sensor researched for its role in supporting energy levels in cells throughout the body, promoting healthy mitochondrial biogensis, and supporting healthy transport of glucose.*

Based on the above, the powerful proprietary GU-MCT810 complex in GlucodOX™  can help maintain and support:

  • Blood glucose levels already within the normal range*
  • Healthy cholesterol levels already within the normal range *
  • Enhanced cellular energy throughout the body*
  • Balanced formation of fat cells and levels of fat storage*

GlucodOX™ is an effective addition to a healthy diet. It helps to promote healthy metabolic pathways that affect cellular energy, glucose utilization, and cholesterol regulation.  In combination with a healthy diet and exercise, GlucodOX™ can help you increase energy and stay healthy, longer.*

GlucodOX™ helps enhance cellular energy and regulate
Glucose and Cholesterol levels already within the normal range…
Lower the risk, let GlucodOX™ help you stay normal, longer
With increased energy and vitality.*

Why Ingredients from Wilke Resources?

Wilke Resources is a respected name in quality bulk nutritional supplements, offering raw ingredient products to the pharmaceutical, health-nutrition, and animal health markets. Wilke serves as both a sales and marketing agent for selected U.S. manufacturers and provides high-quality bulk dietary supplement ingredients through its China Direct sourcing program.



*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

As a supplier of bulk dietary supplement ingredients, it is not our intent to suggest that our customers may claim that our ingredients prevent, treat, or cure any infection or disease or remedy any other condition. Our ingredients may promote the whole health and wellness of specific body systems when taken as directed. Consumers should consult their physicians before adding any dietary supplement to their daily wellness program.



  1. Claudel T, Staels B, Kuipers F. The farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol. 2005; 25(10):2020-30.
  2. Lage R, Dieguez C, Vidal-Puig A, Lopez M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends in Molec Med. 2008;14:539-549.
  3. Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest. 2006;116:1776-1783.
  4. Steinberg GR, Kemp BE. AMPK in health and disease. Physiol Rev. 2009;89:1025-1078.
  5. Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase-development of the energy sensor concept. J Physiol. 2006;574:7-15.
  6. Stayrook KR, Bramlett KS, Savkur RS, Ficorilli J. et al. Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor. Endocrinology. 2005;146(3):984-991.
  7. Lim CT, Kola B. et al.  AMPK as a mediator of hormonal signaling. Endocrinology 2010;44: 87-97.
  8. Osler ME and Zierath JR. Minireview: Adenosine’5’-Monophosphate-Activated Protein Kinase Regulation of Fatty Acid Oxidation in Skeletal Muscle. Endocrinology 2008;149: 935-941.
  9. Sharma B, Salunke R, et al. Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats. Food Chem Toxicol. 2009; 47(10):2631-9.
  10. Yang J-H, Della-Fera MA. Baile CA. Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells. Obesity. 2008;16:16-22.
  11. Rizzo G, Disante M, Mencarelli, The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. Mol Pharmacol. 2006; 70:1164-1173.
  12. Nityanand S, et al.  Clinical trials with guggulipid. A new hypolipidaemic agent.  J Assoc Physicians India. 1989;37:323-28.
  13. Gopal K, et al.  Clinical trial of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipidemia.  J Assoc Physicians India. 1986;34:249-51.
  14. Agarwal R, et al.  Clinical trials of guggulipid – a new hypolipidemic agent of plant origin in primary hyperlipidemia.  Indian J Med Res. 1986;84:626-34.
  15. Canto C, Gerhart-Hines Z, Feige JN, AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458:1056-1062.
  16. Izzat NN, Deshazer ME, and Loose-Mitchell DS.  New Molecular Targets for Cholesterol Lowering Therapy.  Perspectives in Pharmacology. 2000; 293(2): 315-320.
  17. Hardie DG. The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci. 2004;117:5479-5487.
  18. Gruzman A, Sasson S. Adenosine monophosphate-activated protein kinase (AMPK) as a new target for antidiabetic drugs: A review on metabolic, pharmacologic and chemical considerations. Rev Diabet Stud. 2009;6:13-36.
  19. Urizar NL, Liverman AB, Dodds DT, A natural product that lowers cholesterol as an agonist ligand for FXR. Science. 2002;296:1703-1707.
  20. Yang J-H, Della-Fear MA, Rayalam S, Ambati S, Baile CA. Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus guggulsterone in 3T3-L1 adipocytes. BioFactors. 2008;30:159-169.